Esso Capsules contain Esomeprazole, a potent proton pump inhibitor (PPI) that effectively reduces stomach acid production. By selectively inhibiting the H+/K+ ATPase enzyme system in the gastric parietal cells, Esomeprazole provides symptomatic relief and promotes healing of acid-related damage in the gastrointestinal tract. Esso is designed for the treatment of various acid-related disorders and is available in convenient capsule form.
Ingredients
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- Esomeprazole Magnesium or Esomeprazole Sodium – 20 mg or 40 mg per capsule
Uses:
- Gastroesophageal Reflux Disease (GERD): Esso is used to relieve symptoms of GERD such as heartburn and acid regurgitation by reducing stomach acid.
- Peptic Ulcer Disease: It aids in the healing of peptic ulcers and helps prevent their recurrence.
- Erosive Esophagitis: Effective in treating inflammation of the esophagus caused by acid reflux.
- Zollinger-Ellison Syndrome: Helps manage this condition characterized by excessive gastric acid production.
- Helicobacter pylori Eradication: Used in combination with antibiotics to eradicate H. pylori infection and promote ulcer healing.
Dosage
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Adults
- GERD: 20 mg to 40 mg once daily, for up to 4-8 weeks, based on response.
- Peptic Ulcer: 20 mg to 40 mg once daily for 4-8 weeks.
- Erosive Esophagitis: 20 mg to 40 mg once daily for 4-8 weeks.
- Zollinger-Ellison Syndrome: Initial dose of 40 mg twice daily, adjusted according to clinical response.
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Pediatric Use
- For children over 1 year old, the dosage is based on weight and specific condition. Consult a healthcare provider for precise dosing instructions.
Administration
- Capsules should be swallowed whole with water. Do not chew, crush, or dissolve the capsules to maintain efficacy.
- Ideally, take before meals for optimal absorption.
Warnings
- Hypersensitivity Reactions: Severe allergic reactions may occur; discontinue use and seek medical attention if symptoms appear.
- Liver Impairment: Use with caution in patients with liver disease; dose adjustment may be required.
- Long-Term Use Risks: Extended use can increase the risk of bone fractures, kidney issues, and Clostridium difficile infections. Regular monitoring is advised.
- Vitamin B12 Deficiency: Prolonged use may impair Vitamin B12 absorption.
use in pregnancy
- Category C: Risk cannot be ruled out. Use only if the potential benefit outweighs the potential risk to the fetus. Consult healthcare providers for guidance.
use in lactation
- Esomeprazole is excreted in breast milk in small amounts. It is generally considered safe but use with caution. Consult a healthcare provider prior to use while breastfeeding.
Overdose
- Symptoms may include nausea, vomiting, and confusion. Severe cases might result in respiratory or cardiac symptoms. Seek immediate medical attention in case of overdose. Treatment is typically symptomatic and supportive.
Interactions
- Clopidogrel: Esomeprazole may reduce the effectiveness of clopidogrel. Monitor patients closely or consider alternative treatments.
- Warfarin: May enhance the effects of warfarin; regular monitoring of INR is recommended.
- Diazepam: Can increase plasma levels of diazepam; adjust dosage if needed.
- Other PPIs: Concurrent use with other PPIs or medications that increase gastric pH may lead to adverse effects.
Presentation
- Packaging: Available in blister packs or bottles.
- Dosage Forms: Capsules are typically provided in 20 mg or 40 mg strengths, with distinct color and imprint for identification.
Storage
- Store at room temperature (15°C to 30°C).
- Keep away from moisture and heat.
- Keep out of reach of children.
Patient Counseling Information
- Instruct patients to adhere to the prescribed dosage and report any severe or unusual side effects.
- Educate on proper administration of the capsules and the importance of following the treatment regimen.
This detailed profile of Esso Capsules provides essential information for healthcare professionals to ensure safe and effective use in managing acid-related conditions.
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